Effectiveness of nestroft as a screening test for the detection of β-thalassemia trait
نویسندگان
چکیده
The present study was carried out to evaluate the effectiveness of NESTROFT as a screening test for β-thalassemia trait. Naked Eye Single Tube Red cell Osmotic Fragility Test [NESTROFT] is an uncumbersome and inexpensive test for the detection of βthalassemia. NESTROFT was applied to 150 patients of β-thalassemia trait and 150 normal control samples. The test was successful in detecting 143 subjects with β thalassemia trait, and negative in all 150 control samples. Sensitivity of the test was 95.2% and specificity was 62.6%. Positive predictive value of NESTROFT was 60.5% and Negative predictive value of NESTROFT was 89.0%. NESTROFT is suitable for screening the suspected cases of β-thalassemia trait as it is easy to perform, can be used for field studies, inexpensive and does not require any sophisticated equipments. NESTORFT is found to be singly most cost effective and promising screening test to detect thalassemia heterozygotes. © 2014 Sjournals. All rights reserved.
منابع مشابه
Beta-Thalassemia Carrier Detection by NESTROFT: An Answer in Rural Scenario?
Background and Objectives: Beta-thalassemia continues to be a cause of significant burden to the society particularly in the poorer developing countries. Although sophisticated methods of screening have become available, a hunt for a cheap, rapid, objective screening method still remains elusive. Thus, the objectives are to study the validity of Naked-Eye-Single-Tube-Osmotic-Fragility-Test (NES...
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متن کاملBeta-Thalassemia Carrier Detection by NESTROFT: An Answer in Rural Scenario?
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